Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Under endoplasmic reticulum (ER) stress, unfolded proteins accumulate in the ER to activate the ER transmembrane kinase/endoribonuclease (RNase)—IRE1α. IRE1α oligomerizes, autophosphorylates, and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). Here we show that...

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Bibliographic Details
Main Authors: Wang, Likun, Perera, B. Gayani K., Hari, Sanjay B., Bhhatarai, Barun, Backes, Bradley J., Seeliger, Markus A., Schürer, Stephan C., Oakes, Scott A., Papa, Feroz R., Maly, Dustin J.
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508346/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508346/

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