Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease*

Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease*

Inositol-requiring enzyme 1 (IRE1) is the most highly conserved signaling node of the unfolded protein response (UPR) and represents a potential therapeutic target for a number of diseases associated with endoplasmic reticulum stress. IRE1 activates the XBP-1 transcription factor by site-specific cl...

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Bibliographic Details
Main Authors: Volkmann, Kori, Lucas, Julie L., Vuga, Danka, Wang, Xiaoping, Brumm, Duane, Stiles, Caryn, Kriebel, David, Der-Sarkissian, Ani, Krishnan, Kris, Schweitzer, Colleen, Liu, Zheng, Malyankar, Uriel M., Chiovitti, David, Canny, Marella, Durocher, Dan, Sicheri, Frank, Patterson, John B.
Format: Online
Language:English
Published: American Society for Biochemistry and Molecular Biology 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069474/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069474/

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