Somatic Mutations of PIK3R1 Promote Gliomagenesis

Somatic Mutations of PIK3R1 Promote Gliomagenesis

The phosphoinositide 3-kinase (PI3K) pathway is targeted for frequent alteration in glioblastoma (GBM) and is one of the core GBM pathways defined by The Cancer Genome Atlas. Somatic mutations of PIK3R1 are observed in multiple tumor types, but the tumorigenic activity of these mutations has not bee...

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Bibliographic Details
Main Authors: Quayle, Steven N., Lee, Jennifer Y., Cheung, Lydia W T., Ding, Li, Wiedemeyer, Ruprecht, Dewan, Robert W., Huang-Hobbs, Emmet, Zhuang, Li, Wilson, Richard K., Ligon, Keith L., Mills, Gordon B., Cantley, Lewis C., Chin, Lynda
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498106/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498106/

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