Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency
The cytokine leukemia inhibitory factor (Lif) sustains self-renewal of mouse embryonic and induced pluripotent stem cells by activating Jak kinase and the transcription factor Stat3. Here we investigate whether Jak/Stat3 may also contribute to induction of pluripotency. EpiSCs derived from postimpla...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459098/ |