NANOG Amplifies STAT3 Activation and They Synergistically Induce the Naive Pluripotent Program

Reprogramming of a differentiated cell back to a naive pluripotent identity is thought to occur by several independent mechanisms. Two such mechanisms include NANOG and activated STAT3 (pSTAT3), known master regulators of naive pluripotency acquisition [1–5]. Here, we investigated the relationship b...

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Bibliographic Details
Main Authors: Stuart, Hannah T., van Oosten, Anouk L., Radzisheuskaya, Aliaksandra, Martello, Graziano, Miller, Anzy, Dietmann, Sabine, Nichols, Jennifer, Silva, José C.R.
Format: Online
Language:English
Published: Cell Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982126/