The Conserved Residue Arg46 in the N-Terminal Heptad Repeat Domain of HIV-1 gp41 Is Critical for Viral Fusion and Entry

The Conserved Residue Arg46 in the N-Terminal Heptad Repeat Domain of HIV-1 gp41 Is Critical for Viral Fusion and Entry

During the process of HIV-1 fusion with the target cell, the N-terminal heptad repeat (NHR) of gp41 interacts with the C-terminal heptad repeat (CHR) to form fusogenic six-helix bundle (6-HB) core. We previously identified a crucial residue for 6-HB formation and virus entry - Lys63 (K63) in the C-t...

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Bibliographic Details
Main Authors: Wang, Xiaoyi, Xiong, Weiliang, Ma, Xiaochu, Wei, Meili, Chen, Yanxia, Lu, Lu, Debnath, Asim K., Jiang, Shibo, Pan, Chungen
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436870/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436870/

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