Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection

Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection

Peptides derived from the N-terminal heptad repeat (NHR) of HIV-1 gp41 can be potent inhibitors against viral entry when presented in a nonaggregating trimeric coiled-coil conformation via the introduction of exogenous trimerization motifs and intermolecular disulfide bonds. We recently discovered t...

Full description

Bibliographic Details
Main Authors: Wang, Chao, Li, Xue, Yu, Fei, Lu, Lu, Jiang, Xifeng, Xu, Xiaoyu, Wang, Huixin, Lai, Wenqing, Zhang, Tianhong, Zhang, Zhenqing, Ye, Ling, Jiang, Shibo, Liu, Keliang
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999862/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999862/

Similar Items