Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib

Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib

Poly(ADP-ribose) polymerase (PARP) is an enzyme involved in DNA repair. PARP inhibitors can act as chemosensitizers, or operate on the principle of synthetic lethality when used as single agent. Clinical trials have shown drugs in this class to be promising for BRCA mutation carriers. We postulated...

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Bibliographic Details
Main Authors: Daemen, Anneleen, Wolf, Denise M., Korkola, James E., Griffith, Obi L., Frankum, Jessica R., Brough, Rachel, Jakkula, Lakshmi R., Wang, Nicholas J., Natrajan, Rachael, Reis-Filho, Jorge S., Lord, Christopher J., Ashworth, Alan, Spellman, Paul T., Gray, Joe W., van’t Veer, Laura J.
Format: Online
Language:English
Published: Springer US 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429780/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429780/

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