A Genetic Screen Using the PiggyBac Transposon in Haploid Cells Identifies Parp1 as a Mediator of Olaparib Toxicity

A Genetic Screen Using the PiggyBac Transposon in Haploid Cells Identifies Parp1 as a Mediator of Olaparib Toxicity

Genetic perturbation screens have the potential to dissect a wide range of cellular phenotypes. Such screens have historically been difficult in diploid mammalian cells. The recent derivation of haploid embryonic stem cells provides an opportunity to cause loss of function mutants with a random muta...

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Bibliographic Details
Main Authors: Pettitt, Stephen J., Rehman, Farah L., Bajrami, Ilirjana, Brough, Rachel, Wallberg, Fredrik, Kozarewa, Iwanka, Fenwick, Kerry, Assiotis, Ioannis, Chen, Lina, Campbell, James, Lord, Christopher J., Ashworth, Alan
Format: Online
Language:English
Published: Public Library of Science 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636235/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636235/

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