Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function

We have previously synthesized a caged form of the use-dependent N-methyl-D-aspartate (NMDA) receptor ion channel blocker MK801 and used intracellular photolysis of this compound to demonstrate the subcellular location of NMDA receptor ion channels involved in synaptic plasticity. Here, we discuss c...

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Main Authors:	Reeve, James E., Kohl, Michael M., Rodríguez-Moreno, Antonio, Paulsen, Ole, Anderson, Harry L.
Format:	Online
Language:	English
Published:	Landes Bioscience 2012
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419105/

id	pubmed-3419105
recordtype	oai_dc
spelling	pubmed-34191052012-08-15 Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function Reeve, James E. Kohl, Michael M. Rodríguez-Moreno, Antonio Paulsen, Ole Anderson, Harry L. Short Communication We have previously synthesized a caged form of the use-dependent N-methyl-D-aspartate (NMDA) receptor ion channel blocker MK801 and used intracellular photolysis of this compound to demonstrate the subcellular location of NMDA receptor ion channels involved in synaptic plasticity. Here, we discuss considerations regarding the choice of caging molecule, synthesis and the potential uses for caged ion channel blockers in neurophysiology. Landes Bioscience 2012-05-01 /pmc/articles/PMC3419105/ /pubmed/22896783 http://dx.doi.org/10.4161/cib.19400 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Reeve, James E. Kohl, Michael M. Rodríguez-Moreno, Antonio Paulsen, Ole Anderson, Harry L.
spellingShingle	Reeve, James E. Kohl, Michael M. Rodríguez-Moreno, Antonio Paulsen, Ole Anderson, Harry L. Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
author_facet	Reeve, James E. Kohl, Michael M. Rodríguez-Moreno, Antonio Paulsen, Ole Anderson, Harry L.
author_sort	Reeve, James E.
title	Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
title_short	Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
title_full	Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
title_fullStr	Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
title_full_unstemmed	Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
title_sort	caged intracellular nmda receptor blockers for the study of subcellular ion channel function
description	We have previously synthesized a caged form of the use-dependent N-methyl-D-aspartate (NMDA) receptor ion channel blocker MK801 and used intracellular photolysis of this compound to demonstrate the subcellular location of NMDA receptor ion channels involved in synaptic plasticity. Here, we discuss considerations regarding the choice of caging molecule, synthesis and the potential uses for caged ion channel blockers in neurophysiology.
publisher	Landes Bioscience
publishDate	2012
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419105/
_version_	1611549677368377344

Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function

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