Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice
Locally acting insulin growth factor isoform (mIGF-1) and the NAD+-dependent protein deacetylase SIRT1 are implicated in life and health span. Heart failure is associated with aging and is a major cause of death. mIGF-1 protects the heart from oxidative stresses via SIRT1. SIRT1 subcellular localiza...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2012
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409677/ |