Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice

Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice

Locally acting insulin growth factor isoform (mIGF-1) and the NAD+-dependent protein deacetylase SIRT1 are implicated in life and health span. Heart failure is associated with aging and is a major cause of death. mIGF-1 protects the heart from oxidative stresses via SIRT1. SIRT1 subcellular localiza...

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Bibliographic Details
Main Authors: Bolasco, Giulia, Calogero, Raffaele, Carrara, Matteo, Al Banchaabouchi, Mumna, Bilbao, Daniel, Mazzoccoli, Gianluigi, Vinciguerra, Manlio
Format: Online
Language:English
Published: Impact Journals LLC 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409677/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409677/

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