Long telomeres bypass the requirement for telomere maintenance in human tumorigenesis

Despite the importance of telomere maintenance in cancer cell survival via the elongation of telomeres by telomerase reverse transcriptase (TERT) or Alternative Lengthening of Telomeres (ALT), it had not been tested directly whether telomere maintenance is dispensable for human tumorigenesis. We eng...

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Bibliographic Details
Main Authors: Taboski, Michael A. S., Sealey, David C. F., Dorrens, Jennifer, Tayade, Chandrakant, Betts, Dean H., Harrington, Lea
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406325/