Long Telomeres are Preferentially Extended During Recombination-Mediated Telomere Maintenance

Most human somatic cells do not express telomerase. Consequently, with each cell division their telomeres progressively shorten until replicative senescence is induced. Approximately 15% of human cancers maintain their telomeres using telomerase-independent, recombination-based mechanisms collective...

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Bibliographic Details
Main Authors: Chang, Michael, Dittmar, John C., Rothstein, Rodney
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071861/