Prevention and Mitigation of Acute Radiation Syndrome in Mice by Synthetic Lipopeptide Agonists of Toll-Like Receptor 2 (TLR2)

Prevention and Mitigation of Acute Radiation Syndrome in Mice by Synthetic Lipopeptide Agonists of Toll-Like Receptor 2 (TLR2)

Bacterial lipoproteins (BLP) induce innate immune responses in mammals by activating heterodimeric receptor complexes containing Toll-like receptor 2 (TLR2). TLR2 signaling results in nuclear factor-kappaB (NF-κB)-dependent upregulation of anti-apoptotic factors, anti-oxidants and cytokines, all of...

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Main Authors: Shakhov, Alexander N., Singh, Vijay K., Bone, Frederick, Cheney, Alec, Kononov, Yevgeniy, Krasnov, Peter, Bratanova-Toshkova, Troitza K., Shakhova, Vera V., Young, Jason, Weil, Michael M., Panoskaltsis-Mortari, Angela, Orschell, Christie M., Baker, Patricia S., Gudkov, Andrei, Feinstein, Elena
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314012/

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