T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer
During their development, tumors acquire multiple capabilities that enable them to proliferate, disseminate and evade immunosurveillance. A putative mechanism is through the production of the cytokine TGF-β1. We showed in our recent studies that T cell-produced TGF-β1 inhibits antitumor T cell respo...
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| Format: | Online |
| Language: | English |
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Impact Journals LLC
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282091/ |
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pubmed-3282091 |
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pubmed-32820912012-02-22 T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer Sarkar, Abira Donkor, Moses K. Li, Ming O. Research Perspectives During their development, tumors acquire multiple capabilities that enable them to proliferate, disseminate and evade immunosurveillance. A putative mechanism is through the production of the cytokine TGF-β1. We showed in our recent studies that T cell-produced TGF-β1 inhibits antitumor T cell responses to foster tumor growth raising the question of the precise function of TGF-β1 produced by tumor cells in tumor development. Here, using a transgenic model of mammary cancer, we report that deletion of TGF-β1 from tumor cells did not protect mice from tumor development. However, ablation of TGF-β1 from T cells significantly inhibited mammary tumor growth. Additionally, absence of TGF-β1 in T cells prevented tumors from advancing to higher pathological grades and further suppressed secondary tumor development in the lungs. These findings reveal T cells but not tumor cells as a critical source of TGF-β1 that promotes tumor development. Impact Journals LLC 2011-12-31 /pmc/articles/PMC3282091/ /pubmed/22248703 Text en Copyright: © 2011 Sarkar et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Sarkar, Abira Donkor, Moses K. Li, Ming O. |
| spellingShingle |
Sarkar, Abira Donkor, Moses K. Li, Ming O. T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer |
| author_facet |
Sarkar, Abira Donkor, Moses K. Li, Ming O. |
| author_sort |
Sarkar, Abira |
| title |
T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer |
| title_short |
T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer |
| title_full |
T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer |
| title_fullStr |
T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer |
| title_full_unstemmed |
T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer |
| title_sort |
t cell- but not tumor cell-produced tgf-β1 promotes the development of spontaneous mammary cancer |
| description |
During their development, tumors acquire multiple capabilities that enable them to proliferate, disseminate and evade immunosurveillance. A putative mechanism is through the production of the cytokine TGF-β1. We showed in our recent studies that T cell-produced TGF-β1 inhibits antitumor T cell responses to foster tumor growth raising the question of the precise function of TGF-β1 produced by tumor cells in tumor development. Here, using a transgenic model of mammary cancer, we report that deletion of TGF-β1 from tumor cells did not protect mice from tumor development. However, ablation of TGF-β1 from T cells significantly inhibited mammary tumor growth. Additionally, absence of TGF-β1 in T cells prevented tumors from advancing to higher pathological grades and further suppressed secondary tumor development in the lungs. These findings reveal T cells but not tumor cells as a critical source of TGF-β1 that promotes tumor development. |
| publisher |
Impact Journals LLC |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282091/ |
| _version_ |
1611506919520862208 |