Overcoming natural replication barriers: differential helicase requirements

DNA sequences that form secondary structures or bind protein complexes are known barriers to replication and potential inducers of genome instability. In order to determine which helicases facilitate DNA replication across these barriers, we analyzed fork progression through them in wild-type and mu...

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Bibliographic Details
Main Authors: Anand, Ranjith P., Shah, Kartik A., Niu, Hengyao, Sung, Patrick, Mirkin, Sergei M., Freudenreich, Catherine H.
Format: Online
Language:English
Published: Oxford University Press 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273818/