TGFBR1 Intralocus Epistatic Interaction as a Risk Factor for Colorectal Cancer

TGFBR1 Intralocus Epistatic Interaction as a Risk Factor for Colorectal Cancer

In colorectal cancer (CRC), an inherited susceptibility risk affects about 35% of patients, whereas high-penetrance germline mutations account for <6% of cases. A considerable proportion of sporadic tumors could be explained by the coinheritance of multiple low-penetrance variants, some of which...

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Bibliographic Details
Main Authors: Martinez-Canto, Ana, Castillejo, Adela, Mata-Balaguer, Trinidad, Castillejo, Maria-Isabel, Hernandez-Illan, Eva, Irles, Esperanza, Barbera, Victor Manuel, Egoavil, Cecilia, Guarinos, Carla, Alenda, Cristina, Ochoa, Enrique, Lazaro, Rafael, Fajardo, Silvia, Lacueva, Javier, Calpena, Rafael, Soto, Jose Luis
Format: Online
Language:English
Published: Public Library of Science 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264637/

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