PLCζ causes Ca2+ oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P2
At fertilization the sperm causes InsP3 production and Ca2+ release by introducing phospholipase C ζ (PLCζ) into the egg. This sperm PLCζ does not cause hydrolysis of plasma membrane PIP2. Instead it hydrolyzes PIP2 found in intracellular membranes. Fertilization may involve a novel aspect of the In...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258180/ |