Novel regulation of PLCζ activity via its XY-linker
The XY-linker region of somatic cell PLC (phospholipase)-β, -γ, -δ and -ϵ isoforms confers potent catalytic inhibition, suggesting a common auto-regulatory role. Surprisingly, the sperm PLCζ XY-linker does not mediate auto-inhibition. Unlike for somatic PLCs, the absence of the PLCζ XY-linker signif...
| Main Authors: | , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Portland Press Ltd.
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195331/ |