Novel Insights into the Molecular Mechanisms Governing Mdm2 Ubiquitination and Destruction
The Mdm2/p53 pathway is compromised in more than 50% of all human cancers, therefore it is an intensive area of research to understand the upstream regulatory pathways governing Mdm2/p53 activity. Mdm2 is frequently overexpressed in human cancers while the molecular mechanisms underlying the timely...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Impact Journals LLC
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248122/ |