Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2

Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2

Mdm2, a ubiquitin ligase and downstream effector of p53, attenuates the proliferative potential of primary cells via ubiquitination and degradation of the glycolytic enzyme PGAM under senescence-inducing stress.

Bibliographic Details
Main Authors: Mikawa, Takumi, Maruyama, Takeshi, Okamoto, Koji, Nakagama, Hitoshi, Lleonart, Matilde E., Tsusaka, Takeshi, Hori, Kousuke, Murakami, Itsuo, Izumi, Taisuke, Takaori-Kondo, Akifumi, Yokode, Masayuki, Peters, Gordon, Beach, David, Kondoh, Hiroshi
Format: Online
Language:English
Published: The Rockefeller University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941061/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941061/

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