MDM2–MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance
Murine double minute 2 (MDM2) and 4 (MDM4) are known as the main negative regulators of p53, a tumor suppressor. They are able to form heterodimers that are much more effective in the downregulation of p53. Therefore, the MDM2–MDM4 complex could be a target for promising therapeutic restoration of p...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Dove Medical Press
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012629/ |