Antiproliferative Effect of Aaptamine on Human Chronic Myeloid Leukemia K562 Cells
We previously isolated aaptamine, a benzonaphthyridine alkaloid, from marine sponge Aaptos suberitoids. In this study, we investigated the anti-proliferative effect of aaptamine on chronic myeloid leukemia (CML) K562 cells. Aaptamine inhibited growth of K562 with a GI50 as 10 μM, and arrested cell c...
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Bibliographic Details
| Main Authors: |
Jin, Meihua,
Zhao, Wennan,
Zhang, Yanwen,
Kobayashi, Motomasa,
Duan, Hongquan,
Kong, Dexin |
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| Format: | Online
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| Language: | English |
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| Published: |
Molecular Diversity Preservation International (MDPI)
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233409/
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