β-Actin specifically controls cell growth, migration, and the G-actin pool
Targeted deletion of Actb demonstrates that the β-actin gene, in contrast to the γ-actin gene, is an essential gene uniquely required for cell growth and migration. Cell motility and growth defects in β-actin–knockout primary cells are due to a specific role for β-actin in regulating gene expression...
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The American Society for Cell Biology
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204067/ |
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pubmed-32040672012-01-16 β-Actin specifically controls cell growth, migration, and the G-actin pool Bunnell, Tina M. Burbach, Brandon J. Shimizu, Yoji Ervasti, James M. Articles Targeted deletion of Actb demonstrates that the β-actin gene, in contrast to the γ-actin gene, is an essential gene uniquely required for cell growth and migration. Cell motility and growth defects in β-actin–knockout primary cells are due to a specific role for β-actin in regulating gene expression through control of the cellular G-actin pool. The American Society for Cell Biology 2011-11-01 /pmc/articles/PMC3204067/ /pubmed/21900491 http://dx.doi.org/10.1091/mbc.E11-06-0582 Text en © 2011 Bunnell et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Bunnell, Tina M. Burbach, Brandon J. Shimizu, Yoji Ervasti, James M. |
| spellingShingle |
Bunnell, Tina M. Burbach, Brandon J. Shimizu, Yoji Ervasti, James M. β-Actin specifically controls cell growth, migration, and the G-actin pool |
| author_facet |
Bunnell, Tina M. Burbach, Brandon J. Shimizu, Yoji Ervasti, James M. |
| author_sort |
Bunnell, Tina M. |
| title |
β-Actin specifically controls cell growth, migration, and the G-actin pool |
| title_short |
β-Actin specifically controls cell growth, migration, and the G-actin pool |
| title_full |
β-Actin specifically controls cell growth, migration, and the G-actin pool |
| title_fullStr |
β-Actin specifically controls cell growth, migration, and the G-actin pool |
| title_full_unstemmed |
β-Actin specifically controls cell growth, migration, and the G-actin pool |
| title_sort |
β-actin specifically controls cell growth, migration, and the g-actin pool |
| description |
Targeted deletion of Actb demonstrates that the β-actin gene, in contrast to the γ-actin gene, is an essential gene uniquely required for cell growth and migration. Cell motility and growth defects in β-actin–knockout primary cells are due to a specific role for β-actin in regulating gene expression through control of the cellular G-actin pool. |
| publisher |
The American Society for Cell Biology |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204067/ |
| _version_ |
1611484398004207616 |