STARD4 abundance regulates sterol transport and sensing

The expression of a small sterol transport protein, STARD4, is regulated by cholesterol levels. We show that the abundance of STARD4 regulates the sensitivity of the SREBP-2 system to changes in cholesterol, providing an additional layer of regulation in the cholesterol homeostatic mechanism.

Bibliographic Details
Main Authors:	Mesmin, Bruno, Pipalia, Nina H., Lund, Frederik W., Ramlall, Trudy F., Sokolov, Anna, Eliezer, David, Maxfield, Frederick R.
Format:	Online
Language:	English
Published:	The American Society for Cell Biology 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204063/

id	pubmed-3204063
recordtype	oai_dc
spelling	pubmed-32040632012-01-16 STARD4 abundance regulates sterol transport and sensing Mesmin, Bruno Pipalia, Nina H. Lund, Frederik W. Ramlall, Trudy F. Sokolov, Anna Eliezer, David Maxfield, Frederick R. Articles The expression of a small sterol transport protein, STARD4, is regulated by cholesterol levels. We show that the abundance of STARD4 regulates the sensitivity of the SREBP-2 system to changes in cholesterol, providing an additional layer of regulation in the cholesterol homeostatic mechanism. The American Society for Cell Biology 2011-11-01 /pmc/articles/PMC3204063/ /pubmed/21900492 http://dx.doi.org/10.1091/mbc.E11-04-0372 Text en © 2011 Mesmin et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Mesmin, Bruno Pipalia, Nina H. Lund, Frederik W. Ramlall, Trudy F. Sokolov, Anna Eliezer, David Maxfield, Frederick R.
spellingShingle	Mesmin, Bruno Pipalia, Nina H. Lund, Frederik W. Ramlall, Trudy F. Sokolov, Anna Eliezer, David Maxfield, Frederick R. STARD4 abundance regulates sterol transport and sensing
author_facet	Mesmin, Bruno Pipalia, Nina H. Lund, Frederik W. Ramlall, Trudy F. Sokolov, Anna Eliezer, David Maxfield, Frederick R.
author_sort	Mesmin, Bruno
title	STARD4 abundance regulates sterol transport and sensing
title_short	STARD4 abundance regulates sterol transport and sensing
title_full	STARD4 abundance regulates sterol transport and sensing
title_fullStr	STARD4 abundance regulates sterol transport and sensing
title_full_unstemmed	STARD4 abundance regulates sterol transport and sensing
title_sort	stard4 abundance regulates sterol transport and sensing
description	The expression of a small sterol transport protein, STARD4, is regulated by cholesterol levels. We show that the abundance of STARD4 regulates the sensitivity of the SREBP-2 system to changes in cholesterol, providing an additional layer of regulation in the cholesterol homeostatic mechanism.
publisher	The American Society for Cell Biology
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204063/
_version_	1611484395628134400

STARD4 abundance regulates sterol transport and sensing

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