STARD4 abundance regulates sterol transport and sensing

STARD4 abundance regulates sterol transport and sensing

The expression of a small sterol transport protein, STARD4, is regulated by cholesterol levels. We show that the abundance of STARD4 regulates the sensitivity of the SREBP-2 system to changes in cholesterol, providing an additional layer of regulation in the cholesterol homeostatic mechanism.

Bibliographic Details
Main Authors: Mesmin, Bruno, Pipalia, Nina H., Lund, Frederik W., Ramlall, Trudy F., Sokolov, Anna, Eliezer, David, Maxfield, Frederick R.
Format: Online
Language:English
Published: The American Society for Cell Biology 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204063/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204063/

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