STARD4 abundance regulates sterol transport and sensing
The expression of a small sterol transport protein, STARD4, is regulated by cholesterol levels. We show that the abundance of STARD4 regulates the sensitivity of the SREBP-2 system to changes in cholesterol, providing an additional layer of regulation in the cholesterol homeostatic mechanism.
Bibliographic Details
| Main Authors: |
Mesmin, Bruno,
Pipalia, Nina H.,
Lund, Frederik W.,
Ramlall, Trudy F.,
Sokolov, Anna,
Eliezer, David,
Maxfield, Frederick R. |
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| Format: | Online
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| Language: | English |
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| Published: |
The American Society for Cell Biology
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204063/
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