CAG repeats mimic CUG repeats in the misregulation of alternative splicing

CAG repeats mimic CUG repeats in the misregulation of alternative splicing

Mutant transcripts containing expanded CUG repeats in the untranslated region are a pathogenic factor in myotonic dystrophy type 1 (DM1). The mutant RNA sequesters the muscleblind-like 1 (MBNL1) splicing factor and causes misregulation of the alternative splicing of multiple genes that are linked to...

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Bibliographic Details
Main Authors: Mykowska, Agnieszka, Sobczak, Krzysztof, Wojciechowska, Marzena, Kozlowski, Piotr, Krzyzosiak, Wlodzimierz J.
Format: Online
Language:English
Published: Oxford University Press 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203611/

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