In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats

Polyglutamine diseases, including Huntington’s disease and a number of spinocerebellar ataxias, are caused by expanded CAG repeats that are located in translated sequences of individual, functionally-unrelated genes. Only mutant proteins containing polyglutamine expansions have long been thought to...

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Bibliographic Details
Main Authors: Figura, Grzegorz, Koscianska, Edyta, Krzyzosiak, Wlodzimierz J.
Format: Online
Language:English
Published: MDPI 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581269/