Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion

Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion

Trinucleotide repeat (TNR) expansion is responsible for numerous human neurodegenerative diseases. However, the underlying mechanisms remain unclear. Recent studies have shown that DNA base excision repair (BER) can mediate TNR expansion and deletion by removing base lesions in different locations o...

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Bibliographic Details
Main Authors: Xu, Meng, Lai, Yanhao, Torner, Justin, Zhang, Yanbin, Zhang, Zunzhen, Liu, Yuan
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973345/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973345/

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