Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I

Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I

Although mesenchymal stem cells (MSCs) are the natural source for bone regeneration, the exact mechanisms governing MSC crosstalk with collagen I have not yet been uncovered. Cell adhesion to collagen I is mostly mediated by three integrin receptors – α1β1, α2β1 and α11β1. Using human MSC (hMSC), we...

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Bibliographic Details
Main Authors: Popov, C, Radic, T, Haasters, F, Prall, W C, Aszodi, A, Gullberg, D, Schieker, M, Docheva, D
Format: Online
Language:English
Published: Nature Publishing Group 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199721/

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