Growth Hormone Mediates Pubertal Skeletal Development Independent of Hepatic IGF-1 Production
Deficiencies in either growth hormone (GH) or insulin-like growth factor 1 (IGF-1) are associated with reductions in bone size during growth in humans and animal models. Liver-specific IGF-1-deficient (LID) mice, which have 75% reductions in serum IGF-1, were created previously to separate the effec...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Wiley Subscription Services, Inc., A Wiley Company
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179330/ |