Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening

The first crystal structure is reported of a glutaryl-CoA dehydrogenase in the apo state without flavin adenine dinucleotide cofactor bound. Additional structures with small molecules complexed in the catalytic active site were obtained by fragment-based screening.

Bibliographic Details
Main Authors:	Begley, Darren W., Davies, Douglas R., Hartley, Robert C., Hewitt, Stephen N., Rychel, Amanda L., Myler, Peter J., Van Voorhis, Wesley C., Staker, Bart L., Stewart, Lance J.
Format:	Online
Language:	English
Published:	International Union of Crystallography 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169403/

id	pubmed-3169403
recordtype	oai_dc
spelling	pubmed-31694032011-09-21 Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening Begley, Darren W. Davies, Douglas R. Hartley, Robert C. Hewitt, Stephen N. Rychel, Amanda L. Myler, Peter J. Van Voorhis, Wesley C. Staker, Bart L. Stewart, Lance J. Structural Communications The first crystal structure is reported of a glutaryl-CoA dehydrogenase in the apo state without flavin adenine dinucleotide cofactor bound. Additional structures with small molecules complexed in the catalytic active site were obtained by fragment-based screening. International Union of Crystallography 2011-08-13 /pmc/articles/PMC3169403/ /pubmed/21904051 http://dx.doi.org/10.1107/S1744309111014436 Text en © Begley et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Begley, Darren W. Davies, Douglas R. Hartley, Robert C. Hewitt, Stephen N. Rychel, Amanda L. Myler, Peter J. Van Voorhis, Wesley C. Staker, Bart L. Stewart, Lance J.
spellingShingle	Begley, Darren W. Davies, Douglas R. Hartley, Robert C. Hewitt, Stephen N. Rychel, Amanda L. Myler, Peter J. Van Voorhis, Wesley C. Staker, Bart L. Stewart, Lance J. Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening
author_facet	Begley, Darren W. Davies, Douglas R. Hartley, Robert C. Hewitt, Stephen N. Rychel, Amanda L. Myler, Peter J. Van Voorhis, Wesley C. Staker, Bart L. Stewart, Lance J.
author_sort	Begley, Darren W.
title	Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening
title_short	Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening
title_full	Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening
title_fullStr	Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening
title_full_unstemmed	Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening
title_sort	probing conformational states of glutaryl-coa dehydrogenase by fragment screening
description	The first crystal structure is reported of a glutaryl-CoA dehydrogenase in the apo state without flavin adenine dinucleotide cofactor bound. Additional structures with small molecules complexed in the catalytic active site were obtained by fragment-based screening.
publisher	International Union of Crystallography
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169403/
_version_	1611474434897477632

Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening

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