Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening
The first crystal structure is reported of a glutaryl-CoA dehydrogenase in the apo state without flavin adenine dinucleotide cofactor bound. Additional structures with small molecules complexed in the catalytic active site were obtained by fragment-based screening.
Bibliographic Details
Main Authors: |
Begley, Darren W.,
Davies, Douglas R.,
Hartley, Robert C.,
Hewitt, Stephen N.,
Rychel, Amanda L.,
Myler, Peter J.,
Van Voorhis, Wesley C.,
Staker, Bart L.,
Stewart, Lance J. |
Format: | Online
|
Language: | English |
Published: |
International Union of Crystallography
2011
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169403/
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