Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening

Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening

The first crystal structure is reported of a glutaryl-CoA dehydrogenase in the apo state without flavin adenine dinucleotide cofactor bound. Additional structures with small molecules complexed in the catalytic active site were obtained by fragment-based screening.

Bibliographic Details
Main Authors: Begley, Darren W., Davies, Douglas R., Hartley, Robert C., Hewitt, Stephen N., Rychel, Amanda L., Myler, Peter J., Van Voorhis, Wesley C., Staker, Bart L., Stewart, Lance J.
Format: Online
Language:English
Published: International Union of Crystallography 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169403/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169403/

Similar Items