GagCM9-Specific CD8+ T Cells Expressing Limited Public TCR Clonotypes Do Not Suppress SIV Replication In Vivo

GagCM9-Specific CD8+ T Cells Expressing Limited Public TCR Clonotypes Do Not Suppress SIV Replication In Vivo

Several lines of evidence suggest that HIV/SIV-specific CD8+ T cells play a critical role in the control of viral replication. Recently we observed high levels of viremia in Indian rhesus macaques vaccinated with a segment of SIVmac239 Gag (Gag45–269) that were subsequently infected with SIVsmE660....

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Bibliographic Details
Main Authors: Vojnov, Lara, Martins, Mauricio A., Almeida, Jorge R., Ende, Zachary, Rakasz, Eva G., Reynolds, Matthew R., Leon, Enrique J., Weisgrau, Kim L., Burwitz, Benjamin J., Folkvord, Joy M., Veloso de Santana, Marlon G., Costa Neves, Patrícia C., Connick, Elizabeth, Skinner, Pamela J., Gostick, Emma, O'Connor, David H., Wilson, Nancy A., Bonaldo, Myrna C., Galler, Ricardo, Price, David A., Douek, Danny C., Watkins, David I.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162554/

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