Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies
In cancer chemotherapy neutropenia is a common dose-limiting toxicity. An ability to predict the neutropenic effects of cytotoxic agents based on proposed trial designs and models conditioned on previous studies would be valuable. The aim of this study was to evaluate the ability of a semi-mechanist...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Springer US
2010
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160557/ |