Two-stage model-based design of cancer phase I dose escalation trials: evaluation using the phase I program of barasertib (AZD1152)

by Keizer, Ron J., Zandvliet, Anthe S., Beijnen, Jos H., Schellens, Jan H. M., Huitema, Alwin D. R.
Published 2011

Treatment Individualization in Colorectal Cancer

by van Geel, Robin M. J. M., Beijnen, Jos H., Bernards, René, Schellens, Jan H.M.
Published 2015

Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

by Keizer, Ron J, Jansen, Robert S, Rosing, Hilde, Thijssen, Bas, Beijnen, Jos H, Schellens, Jan H M, Huitema, Alwin D R
Published 2015

Pharmacokinetics of Selected Anticancer Drugs in Elderly Cancer Patients: Focus on Breast Cancer

by Crombag, Marie-Rose B.S., Joerger, Markus, Thürlimann, Beat, Schellens, Jan H.M., Beijnen, Jos H., Huitema, Alwin D.R.
Published 2016

A phase I, open-label, randomized crossover study to assess the effect of dosing of the MEK 1/2 inhibitor Selumetinib (AZD6244; ARRY-142866) in the presence and absence of food in...

by Leijen, Suzanne, Soetekouw, Patricia M. M. B., Jeffry Evans, T. R., Nicolson, Marianne, Schellens, Jan H. M., Learoyd, Maria, Grinsted, Lynda, Zazulina, Victoria, Pwint, Thinn, Middleton, Mark
Published 2011

Phase I and pharmacokinetic study of capecitabine and the oral mTOR inhibitor everolimus in patients with advanced solid malignancies

by Deenen, Maarten J., Klümpen, Heinz-Josef, Richel, Dick J., Sparidans, Rolf W., Weterman, Mariette J., Beijnen, Jos H., Schellens, Jan H. M., Wilmink, Johanna W.
Published 2011

Pharmacokinetics and Excretion of 14C-Bendamustine in Patients with Relapsed or Refractory Malignancy

by Dubbelman, Anne-Charlotte, Rosing, Hilde, Darwish, Mona, D’Andrea, Denise, Bond, Mary, Hellriegel, Edward, Robertson, Philmore, Beijnen, Jos H., Schellens, Jan H. M.
Published 2013

Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy

by van Hasselt, J. G. Coen, Allegaert, Karel, van Calsteren, Kristel, Beijnen, Jos H., Schellens, Jan H. M., Huitema, Alwin D. R.
Published 2014

Long-term safety and anti-tumour activity of olaparib monotherapy after combination with carboplatin and paclitaxel in patients with advanced breast, ovarian or fallopian tube canc...

by van der Noll, Ruud, Marchetti, Serena, Steeghs, Neeltje, Beijnen, Jos H, Mergui-Roelvink, Marja W J, Harms, Emmy, Rehorst, Harriet, Sonke, Gabe S, Schellens, Jan H M
Published 2015

Corrigendum to “Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy”

by van Hasselt, J. G. Coen, Allegaert, Karel, van Calsteren, Kristel, Beijnen, Jos H., Schellens, Jan H. M., Huitema, Alwin D. R.
Published 2015

A phase I followed by a randomized phase II trial of two cycles carboplatin-olaparib followed by olaparib monotherapy versus capecitabine in BRCA1- or BRCA2-mutated HER2-negative a...

by Schouten, Philip C., Dackus, Gwen M. H. E., Marchetti, Serena, van Tinteren, Harm, Sonke, Gabe S., Schellens, Jan H. M., Linn, Sabine C.
Published 2016

Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies

by Soto, Elena, Keizer, Ron J., Trocóniz, Iñaki F., Huitema, Alwin D. R., Beijnen, Jos H., Schellens, Jan H. M., Wanders, Jantien, Cendrós, Josep María, Obach, Rosendo, Peraire, Concepción, Friberg, Lena E., Karlsson, Mats O.
Published 2010

Postoperative serum proteomic profiles may predict recurrence-free survival in high-risk primary breast cancer

by Gast, Marie-Christine W., Zapatka, Marc, van Tinteren, Harm, Bontenbal, Marijke, Span, Paul N., Tjan-Heijnen, Vivianne C. G., Knol, Jaco C., Jimenez, Connie R., Schellens, Jan H. M., Beijnen, Jos H.
Published 2011

Pharmacokinetics and excretion of 14C-omacetaxine in patients with advanced solid tumors

by Nijenhuis, Cynthia M., Hellriegel, Edward, Beijnen, Jos H., Hershock, Diane, Huitema, Alwin D. R., Lucas, Luc, Mergui-Roelvink, Marja, Munteanu, Mihaela, Rabinovich-Guilatt, Laura, Robertson, Philmore, Rosing, Hilde, Spiegelstein, Ofer, Schellens, Jan H. M.
Published 2016

A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignanci...

by Cirkel, Geert A., Kerklaan, Bojana Milojkovic, Vanhoutte, Frédéric, der Aa, Annegret Van, Lorenzon, Giocondo, Namour, Florence, Pujuguet, Philippe, Darquenne, Sophie, de Vos, Filip Y. F., Snijders, Tom J., Voest, Emile E., Schellens, Jan H. M., Lolkema, Martijn P.
Published 2016

A phosphotyrosine switch regulates organic cation transporters

by Sprowl, Jason A., Ong, Su Sien, Gibson, Alice A., Hu, Shuiying, Du, Guoqing, Lin, Wenwei, Li, Lie, Bharill, Shashank, Ness, Rachel A., Stecula, Adrian, Offer, Steven M., Diasio, Robert B., Nies, Anne T., Schwab, Matthias, Cavaletti, Guido, Schlatter, Eberhard, Ciarimboli, Giuliano, Schellens, Jan H. M., Isacoff, Ehud Y., Sali, Andrej, Chen, Taosheng, Baker, Sharyn D., Sparreboom, Alex, Pabla, Navjotsingh
Published 2016

Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis

by Sobral-Leite, Marcelo, Wesseling, Jelle, Smit, Vincent T. H. B. M., Nevanlinna, Heli, van Miltenburg, Martine H., Sanders, Joyce, Hofland, Ingrid, Blows, Fiona M., Coulson, Penny, Patrycja, Gazinska, Schellens, Jan H. M., Fagerholm, Rainer, Heikkilä, Päivi, Aittomäki, Kristiina, Blomqvist, Carl, Provenzano, Elena, Ali, Hamid Raza, Figueroa, Jonine, Sherman, Mark, Lissowska, Jolanta, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Phillips, Kelly-Anne, Couch, Fergus J., Olson, Janet E., Vachon, Celine, Visscher, Daniel, Brenner, Hermann, Butterbach, Katja, Arndt, Volker, Holleczek, Bernd, Hooning, Maartje J., Hollestelle, Antoinette, Martens, John W. M., van Deurzen, Carolien H. M., van de Water, Bob, Broeks, Annegien, Chang-Claude, Jenny, Chenevix-Trench, Georgia, Easton, Douglas F., Pharoah, Paul D. P., García-Closas, Montserrat, de Graauw, Marjo, Schmidt, Marjanka K.
Published 2015