LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding

Leucine rich repeat kinase 2 (LRRK2) is a Parkinson's disease (PD) gene that encodes a large multidomain protein including both a GTPase and a kinase domain. GTPases often regulate kinases within signal transduction cascades, where GTPases act as molecular switches cycling between a GTP bound “...

Full description

Bibliographic Details
Main Authors: Taymans, Jean-Marc, Vancraenenbroeck, Renée, Ollikainen, Petri, Beilina, Alexandra, Lobbestael, Evy, De Maeyer, Marc, Baekelandt, Veerle, Cookson, Mark R.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155532/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155532/

Similar Items