pKa Modulation of the Acid/Base Catalyst within GH32 and GH68: A Role in Substrate/Inhibitor Specificity?

by Yuan, Shuguang, Le Roy, Katrien, Venken, Tom, Lammens, Willem, Van den Ende, Wim, De Maeyer, Marc
Published 2012

LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding

by Taymans, Jean-Marc, Vancraenenbroeck, Renée, Ollikainen, Petri, Beilina, Alexandra, Lobbestael, Evy, De Maeyer, Marc, Baekelandt, Veerle, Cookson, Mark R.
Published 2011

Mapping the Binding Interface between an HIV-1 Inhibiting Intrabody and the Viral Protein Rev

by Vercruysse, Thomas, Boons, Eline, Venken, Tom, Vanstreels, Els, Voet, Arnout, Steyaert, Jan, De Maeyer, Marc, Daelemans, Dirk
Published 2013

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2

by Vancraenenbroeck, Renée, De Raeymaecker, Joren, Lobbestael, Evy, Gao, Fangye, De Maeyer, Marc, Voet, Arnout, Baekelandt, Veerle, Taymans, Jean-Marc
Published 2014

Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers

by Civiero, Laura, Vancraenenbroeck, Renée, Belluzzi, Elisa, Beilina, Alexandra, Lobbestael, Evy, Reyniers, Lauran, Gao, Fangye, Micetic, Ivan, De Maeyer, Marc, Bubacco, Luigi, Baekelandt, Veerle, Cookson, Mark R., Greggio, Elisa, Taymans, Jean-Marc
Published 2012

Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome

by Van den Bossche, An, Hardwick, Steven W, Ceyssens, Pieter-Jan, Hendrix, Hanne, Voet, Marleen, Dendooven, Tom, Bandyra, Katarzyna J, De Maeyer, Marc, Aertsen, Abram, Noben, Jean-Paul, Luisi, Ben F, Lavigne, Rob
Published 2016