Germline Fitness-Based Scoring of Cancer Mutations

A key goal in cancer research is to find the genomic alterations that underlie malignant cells. Genomics has proved successful in identifying somatic variants at a large scale. However, it has become evident that a typical cancer exhibits a heterogenous mutation pattern across samples. Cases where t...

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Bibliographic Details
Main Authors: Fischer, Andrej, Greenman, Chris, Mustonen, Ville
Format: Online
Language:English
Published: Genetics Society of America 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122307/