Traveling Bax and Forth from Mitochondria to Control Apoptosis
Antiapoptotic Bcl-2 proteins on mitochondria inhibit prodeath proteins, such as Bax, which are found primarily in the cytosol. In this issue, Edlich et al., (2011) show that Bax and Bcl-xL interact on the mitochondrial surface and then retrotranslocate to the cytosol, effectively preventing Bax-indu...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072571/ |