Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112

Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112

Human cytomegalovirus (HCMV) UL141 induces protection against natural killer cell-mediated cytolysis by downregulating cell surface expression of CD155 (nectin-like molecule 5; poliovirus receptor), a ligand for the activating receptor DNAM-1 (CD226). However, DNAM-1 is also recognized to bind a sec...

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Bibliographic Details
Main Authors: Prod'homme, Virginie, Sugrue, Daniel M., Stanton, Richard J., Nomoto, Akio, Davies, James, Rickards, Carole R., Cochrane, Daniel, Moore, Melanie, Wilkinson, Gavin W. G., Tomasec, Peter
Format: Online
Language:English
Published: Society for General Microbiology 2010
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052539/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052539/

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