Human Cytomegalovirus Glycoprotein UL141 Targets the TRAIL Death Receptors to Thwart Host Innate Antiviral Defenses

Human Cytomegalovirus Glycoprotein UL141 Targets the TRAIL Death Receptors to Thwart Host Innate Antiviral Defenses

Death receptors (DRs) of the TNFR superfamily contribute to antiviral immunity by promoting apoptosis and regulating immune homeostasis during infection, and viral inhibition of DR signaling can alter immune defenses. Here we identify the human cytomegalovirus (HCMV) UL141 glycoprotein as necessary...

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Bibliographic Details
Main Authors: Smith, Wendell, Tomasec, Peter, Aicheler, Rebecca, Loewendorf, Andrea, Nemčovičová, Ivana, Wang, Eddie C.Y., Stanton, Richard J., Macauley, Matt, Norris, Paula, Willen, Laure, Ruckova, Eva, Nomoto, Akio, Schneider, Pascal, Hahn, Gabriele, Zajonc, Dirk M., Ware, Carl F., Wilkinson, Gavin W.G., Benedict, Chris A.
Format: Online
Language:English
Published: Cell Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601332/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601332/

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