Homocysteine and Familial Longevity: The Leiden Longevity Study
Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease. We aimed to explore the association of homocysteine with familial longevit...
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| Format: | Online |
| Language: | English |
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Public Library of Science
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050884/ |
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pubmed-30508842011-03-15 Homocysteine and Familial Longevity: The Leiden Longevity Study Wijsman, Carolien A. van Heemst, Diana Rozing, Maarten P. Slagboom, P. Eline Beekman, Marian de Craen, Anton J. M. Maier, Andrea B. Westendorp, Rudi G. J. Blom, Henk J. Mooijaart, Simon P. Research Article Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease. We aimed to explore the association of homocysteine with familial longevity by testing whether homocysteine is lower in individuals that are genetically enriched for longevity. We measured concentrations of total homocysteine in 1907 subjects from the Leiden Longevity Study consisting of 1309 offspring of nonagenarian siblings, who are enriched with familial factors promoting longevity, and 598 partners thereof as population controls. We found that homocysteine was related to age, creatinine, folate, vitamin B levels and medical history of hypertension and stroke in both groups (all p<0.001). However, levels of homocysteine did not differ between offspring enriched for longevity and their partners, and no differences in the age-related rise in homocysteine levels were found between groups (p for interaction 0.63). The results suggest that homocysteine metabolism is not likely to predict familial longevity. Public Library of Science 2011-03-08 /pmc/articles/PMC3050884/ /pubmed/21408159 http://dx.doi.org/10.1371/journal.pone.0017543 Text en Wijsman et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Wijsman, Carolien A. van Heemst, Diana Rozing, Maarten P. Slagboom, P. Eline Beekman, Marian de Craen, Anton J. M. Maier, Andrea B. Westendorp, Rudi G. J. Blom, Henk J. Mooijaart, Simon P. |
| spellingShingle |
Wijsman, Carolien A. van Heemst, Diana Rozing, Maarten P. Slagboom, P. Eline Beekman, Marian de Craen, Anton J. M. Maier, Andrea B. Westendorp, Rudi G. J. Blom, Henk J. Mooijaart, Simon P. Homocysteine and Familial Longevity: The Leiden Longevity Study |
| author_facet |
Wijsman, Carolien A. van Heemst, Diana Rozing, Maarten P. Slagboom, P. Eline Beekman, Marian de Craen, Anton J. M. Maier, Andrea B. Westendorp, Rudi G. J. Blom, Henk J. Mooijaart, Simon P. |
| author_sort |
Wijsman, Carolien A. |
| title |
Homocysteine and Familial Longevity: The Leiden Longevity Study |
| title_short |
Homocysteine and Familial Longevity: The Leiden Longevity Study |
| title_full |
Homocysteine and Familial Longevity: The Leiden Longevity Study |
| title_fullStr |
Homocysteine and Familial Longevity: The Leiden Longevity Study |
| title_full_unstemmed |
Homocysteine and Familial Longevity: The Leiden Longevity Study |
| title_sort |
homocysteine and familial longevity: the leiden longevity study |
| description |
Homocysteine concentrations are a read-out of methionine metabolism and have been related to changes in lifespan in animal models. In humans, high homocysteine concentrations are an important predictor of age related disease. We aimed to explore the association of homocysteine with familial longevity by testing whether homocysteine is lower in individuals that are genetically enriched for longevity. We measured concentrations of total homocysteine in 1907 subjects from the Leiden Longevity Study consisting of 1309 offspring of nonagenarian siblings, who are enriched with familial factors promoting longevity, and 598 partners thereof as population controls. We found that homocysteine was related to age, creatinine, folate, vitamin B levels and medical history of hypertension and stroke in both groups (all p<0.001). However, levels of homocysteine did not differ between offspring enriched for longevity and their partners, and no differences in the age-related rise in homocysteine levels were found between groups (p for interaction 0.63). The results suggest that homocysteine metabolism is not likely to predict familial longevity. |
| publisher |
Public Library of Science |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050884/ |
| _version_ |
1611443419108868096 |