The effects of unnatural base pairs and mispairs on DNA duplex stability and solvation
In an effort to develop unnatural DNA base pairs we examined six pyridine-based nucleotides, d3MPy, d4MPy, d5MPy, d34DMPy, d35DMPy and d45DMPy. Each bears a pyridyl nucleobase scaffold but they are differentiated by methyl substitution, and were designed to vary both inter- and intra-strand packing...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Oxford University Press
2009
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724283/ |