KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry

KlenTaq polymerase replicates unnatural base pairs by inducing a Watson-Crick geometry

Many candidate unnatural DNA base pairs have been developed, but surprisingly, some of the best replicated adopt intercalated structures in free DNA that are difficult to reconcile with known mechanisms of polymerase recognition. Here we present crystal structures of KlenTaq DNA polymerase at differ...

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Bibliographic Details
Main Authors: Betz, Karin, Malyshev, Denis A., Lavergne, Thomas, Welte, Wolfram, Diederichs, Kay, Dwyer, Tammy J., Ordoukhanian, Phillip, Romesberg, Floyd E., Marx, Andreas
Format: Online
Language:English
Published: 2012
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690913/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690913/

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