Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin αEβ7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. αE −CD25+ cells expre...

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Main Authors: Huehn, Jochen, Siegmund, Kerstin, Lehmann, Joachim C.U., Siewert, Christiane, Haubold, Uta, Feuerer, Markus, Debes, Gudrun F., Lauber, Joerg, Frey, Oliver, Przybylski, Grzegorz K., Niesner, Uwe, de la Rosa, Maurus, Schmidt, Christian A., Bräuer, Rolf, Buer, Jan, Scheffold, Alexander, Hamann, Alf
Format: Online
Language:English
Published: The Rockefeller University Press 2004
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211798/
id pubmed-2211798
recordtype oai_dc
spelling pubmed-22117982008-03-11 Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells Huehn, Jochen Siegmund, Kerstin Lehmann, Joachim C.U. Siewert, Christiane Haubold, Uta Feuerer, Markus Debes, Gudrun F. Lauber, Joerg Frey, Oliver Przybylski, Grzegorz K. Niesner, Uwe de la Rosa, Maurus Schmidt, Christian A. Bräuer, Rolf Buer, Jan Scheffold, Alexander Hamann, Alf Article Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin αEβ7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. αE −CD25+ cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, αE-positive subsets (CD25+ and CD25−) displayed an effector/memory phenotype expressing high levels of E/P-selectin–binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, αE-expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis. The Rockefeller University Press 2004-02-02 /pmc/articles/PMC2211798/ /pubmed/14757740 http://dx.doi.org/10.1084/jem.20031562 Text en Copyright © 2004, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Huehn, Jochen
Siegmund, Kerstin
Lehmann, Joachim C.U.
Siewert, Christiane
Haubold, Uta
Feuerer, Markus
Debes, Gudrun F.
Lauber, Joerg
Frey, Oliver
Przybylski, Grzegorz K.
Niesner, Uwe
de la Rosa, Maurus
Schmidt, Christian A.
Bräuer, Rolf
Buer, Jan
Scheffold, Alexander
Hamann, Alf
spellingShingle Huehn, Jochen
Siegmund, Kerstin
Lehmann, Joachim C.U.
Siewert, Christiane
Haubold, Uta
Feuerer, Markus
Debes, Gudrun F.
Lauber, Joerg
Frey, Oliver
Przybylski, Grzegorz K.
Niesner, Uwe
de la Rosa, Maurus
Schmidt, Christian A.
Bräuer, Rolf
Buer, Jan
Scheffold, Alexander
Hamann, Alf
Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells
author_facet Huehn, Jochen
Siegmund, Kerstin
Lehmann, Joachim C.U.
Siewert, Christiane
Haubold, Uta
Feuerer, Markus
Debes, Gudrun F.
Lauber, Joerg
Frey, Oliver
Przybylski, Grzegorz K.
Niesner, Uwe
de la Rosa, Maurus
Schmidt, Christian A.
Bräuer, Rolf
Buer, Jan
Scheffold, Alexander
Hamann, Alf
author_sort Huehn, Jochen
title Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells
title_short Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells
title_full Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells
title_fullStr Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells
title_full_unstemmed Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells
title_sort developmental stage, phenotype, and migration distinguish naive- and effector/memory-like cd4+ regulatory t cells
description Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin αEβ7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. αE −CD25+ cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, αE-positive subsets (CD25+ and CD25−) displayed an effector/memory phenotype expressing high levels of E/P-selectin–binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, αE-expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis.
publisher The Rockefeller University Press
publishDate 2004
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211798/
_version_ 1611433855967821824

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