Survivin Loss in Thymocytes Triggers p53-mediated Growth Arrest and p53-independent Cell Death
Because survivin-null embryos die at an early embryonic stage, the role of survivin in thymocyte development is unknown. We have investigated the role by deleting the survivin gene only in the T lineage and show here that loss of survivin blocks the transition from CD4− CD8− double negative (DN) thy...
| Main Authors: | , , , , , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The Rockefeller University Press
2004
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211792/ |